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Indication & Dosage
 
 
Intravenous
SUSCEPTIBLE INFECTIONS
Adult: 0.5-1 g every 8 hr.
 
Intravenous
SUSCEPTIBLE INFECTIONS
Child: Neonate: <7 days: 20 mg/kg 12 hrly (severe infection 40 mg/kg 12 hrly); 7-28 days: 20 mg/kg 8 hrly (severe infection 40 mg/kg 8 hrly). 1-3 mth: 10 mg/kg 8 hrly; >3 mth and <50 kg: 10-20 mg/kg 8 hrly.
 
Intravenous
MENINGITIS
Adult:  0.5-1 g every 8 hr.
 
Intravenous
MENINGITIS
Child:  0.5-1 g every 8 hr.
 
Intravenous
SKIN AND SKIN STRUCTURE INFECTIONS
Child:  0.5-1 g every 8 hr.
 
Intravenous
SKIN AND SKIN STRUCTURE INFECTIONS
Adult:  0.5-1 g every 8 hr.
Max Dosage:  500 mg
 
Intravenous
INTRA-ABDOMINAL INFECTIONS
Child:  0.5-1 g every 8 hr.
 
Intravenous
INTRA-ABDOMINAL INFECTIONS
Adult:  0.5-1 g every 8 hr.
   
Precautions History of hypersensitivity to carbapenem, pencillins or other β-lactam antibiotics; infants <3 mth; renal insufficiency; neurological disorders; pregnancy, lactation. Not recommended for use in MRSA.
   
Potentially Life-threatening 
Adverse Drug Reactions
Diarrhoea, nausea, vomiting, abdominal pain; headache; constipation; rash, pruritus, uticaria; apnoea; phlebitis, thrombophlebitis, swelling and pain at inj site; disturbances in LFTs (may cause increases in serum transaminases, alkaline phosphatase, lactic dehydrogenase). Rarely: erythema multiforme; eosinophilia, thrombocytopenia, leucopenia, neutropenia; seizures and CNS effects reported in patients with underlying CNS disorders or renal impairment.
   
Adverse Drug Reactions Anaphylaxis; pseudomembranous colitis; Stevens-Johnsons sydrome.
   
Interactions Serum levels may be increased by probenecid. May reduce serum valproic acid levels; sub-therapeutic levels may be reached in some patients.
   
   
 

 

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